Enhancement patterns of adrenal nodules on magnetic resonance imaging

ABSTRACT Objective: To compare enhancement patterns of typical adrenal adenomas, lipid-poor adenomas, and non-adenomas on magnetic resonance imaging (MRI). Materials and Methods: Evaluation of adrenal nodules larger than 1.0 cm, with at least 2-year follow-up, evaluated on MRI in January 2007 and December 2016. Two different protocols were included - upper abdomen MRI (delayed phase after 3 minutes) and abdomen and pelvis MRI (delayed phase after 7 minutes) - and nodules were divided in typical adenomas (characterized on out-of-phase MRI sequence), lipid-poor adenomas (based on follow-up imaging stability) and non-adenomas (based on pathological finding or follow-up imaging). T2-weighted and enhancement features were analyzed (absolute and relative washout and enhancement curve pattern), similarly to classic computed tomography equations. Results: Final cohort was composed of 123 nodules in 116 patients (mean diameter of 1.8 cm and mean follow up time of 4 years and 3 months). Of them, 98 (79%) nodules had features of typical adenomas by quantitative chemical shift imaging, and demonstrated type 3 curve pattern in 77%, mean absolute and relative washout of 29% and 16%, respectively. Size, oncologic history and T2-weighted features showed statistically significant differences among groups. Also, a threshold greater than 11.75% for absolute washout on MRI achieved sensitivity of 71.4% and specificity of 70.0%, in differentiating typical adenomas from non-adenomas. Conclusion: Calculating absolute washout of adrenal nodules on MRI may help identifying proportion of non-adenomas.

A comparative study of ultrasound and cross-sectional imaging for detection of small renal masses: anatomic factors and radiologists experience / Estudo comparativo de ultrassonografia e métodos seccionais para detecção de pequenas lesões renais: fatores anatômicos e experiência do radiologista

ABSTRACT Objective: To evaluate anatomic factors and radiologist's experience in the detection of solid renal masses on ultrasonography. Methods: We searched for solid renal masses diagnosed on cross-sectional imaging from 2007 to 2017 that also had previous ultrasonography from the past 6 months. The following features were evaluated: nodule size, laterality, location and growth pattern, patient body mass index and radiologist's experience in ultrasound. In surgically resected cases, pathologic reports were evaluated. Unpaired t test and χ2 test were used to evaluate differences among subgroups, using R-statistics. Statistical significance was set at p<0.05. Results: The initial search of renal nodules on cross-sectional imaging resulted in 428 lesions and 266 lesions were excluded. Final cohort included 162 lesions and, of those, 108 (67%) were correctly detected on ultrasonography (Group 1) and 54 (33%) were missed (Group 2). Comparison of Groups 1 and 2 were as follows, respectively: body mass index (27.7 versus 27.1; p=0.496), size (2.58cm versus 1.74cm; p=0.003), laterality (54% versus 59% right sided; p=0.832), location (27% versus 22% upper pole; p=0.869), growth pattern (25% versus 28% endophytic; p=0.131) and radiologist's experience (p=0.300). From surgically resected cases, histology available for Group 1 was clear cell (n=11), papillary (n=15), chromophobe (n=2) renal cell carcinoma, oncocytoma (n=1), and, for Group 2, clear cell (n=7), papillary (n=5) renal cell carcinoma, oncocytoma (n=2), angiomyolipoma, chromophobe renal cell carcinoma, and interstitial pyelonephritis (n=1, each). Conclusion: Size was the only significant parameter related to renal nodule detection on ultrasound.

RESUMO Objetivo: Avaliar os fatores anatômicos e a experiência do radiologista na detecção de massas renais sólidas na ultrassonografia. Métodos: Buscamos massas renais sólidas diagnosticadas em imagens seccionais, de 2007 a 2017, que também tivessem ultrassonografia prévia nos últimos 6 meses. As seguintes características foram avaliadas: tamanho do nódulo, lateralidade, localização e padrão de crescimento, índice de massa corporal do paciente e experiência do radiologista em ultrassonografia. Nos casos com ressecção cirúrgica, os laudos de patologia foram analisados. O teste t não pareado e o teste χ2 foram utilizados para avaliar as diferenças entre os subgrupos, usando R-statistics. A significância estatística foi estabelecida em p<0,05. Resultados: A pesquisa inicial de nódulos renais achados em imagens seccionais resultou em 428 lesões, com 266 exclusões. A coorte final incluiu 162 lesões e, destas, 108 (67%) foram detectadas corretamente na ultrassonografia (Grupo 1), e 54 (33%) não foram identificadas (Grupo 2). A comparação dos Grupos 1 e 2 mostrou índice de massa corporal (27,7 versus 27,1; p=0,496), tamanho (2,58cm versus 1,74cm; p=0,003), lateralidade (54% versus 59% no lado direito; p=0,832), localização (27% versus 22% no polo superior; p=0,869), padrão de crescimento (25% versus 28% endofítico; p=0,131) e experiência do radiologista (p=0,300). A histologia disponível para o Grupo 1 foi carcinoma renal de células claras (n=11), papilar (n=15), cromófobo (n=2), oncocitoma (n=1), e, para o Grupo 2, carcinoma renal de células claras (n=7), papilar (n=5), oncocitoma (n=2), angiomiolipoma, cromófobo e pielonefrite intersticial (n=1, cada). Conclusão: O tamanho foi o único parâmetro significativo relacionado à detecção de nódulos renais no ultrassom.

Diagnóstico por imagem de Body Packers: relato de caso / Image diagnosis of Body Packers: case report

Introdução: o Brasil é atualmente a principal rota de tráfico de drogas da América Latina. Em aeroportos internacionais, passageiros com perfil considerado como suspeito pela Polícia Federal são conduzidos até serviços de pronto-atendimento para serem avaliados, ainda que assintomáticos e sem alterações visíveis. Objetivos: discutir, a partir de um relato de caso, os métodos de imagem diagnósticos para body packers mais utilizados na prática. Métodos: relato de caso de paciente atendido pelo Centro de Informações e Atendimento Toxicológico (CIAT) do Hospital Pronto-Socorro João XXIII em Belo Horizonte (MG). Resultados: um paciente trazido pela Polícia Federal, que negava ter ingerido pacotes de cocaína e estava assintomático com exame físico normal, foi submetido à propedêutica por imagem. Foi realizado uma tomografia computadorizada (TC) de abdome que evidenciou inúmeros corpos estranhos pelo trato gastrointestinal do paciente. Foi realizado também uma radiografia simples de abdome não foi útil em mostrar com precisão a localização e quantificação dos papelotes. Conclusões: tendo em vista o fato de que a ruptura de um único invólucro pode provocar intoxicação grave e muitas vezes fatal, a ausência de mensuração quantitativa e os falso-negativos da radiografia simples de abdome tornam esse método limitado. Sugerimos que a TC seja o método de imagem inicial, o que garante maior rapidez e precisão no manejo do caso, economia no tempo de estadia do paciente e maior segurança para o mesmo.(AU)

Introduction: Brazil is currently the main drug traffic route of Latin America. At international airports, passengers considered as suspect by the Federal Police are driven to emergency care services to be evaluated, even if asymptomatic and no visible abnormalities. Objectives: discuss, from a case report, the most used in practice diagnostic imaging methods. Methods: case report of patient assisted by the Center for Information and Toxicological Assistance (CIAT), Hospital Pronto-Socorro João XXIII in Belo Horizonte (MG). Results: a patient brought by the Federal Police, denied having ingested packets of cocaine and was asymptomatic with a normal physical examination, underwent imaging workup. A computed tomography (CT) was performed and revealed that many foreign bodies into the gastrointestinal tract of the patient. A plain abdominal x-ray was also made and wasn't helpful in showing the exact location and quantification of packets. Conclusions: considering the fact that the rupture of a single packet can cause severe intoxication, often fatal, the absence of quantitative measurement and the false-negative of plain abdominal x-ray make this method limited. We suggest that CT should be the initial imaging method, which provides greater speed and accuracy in handling the case, reducing the patient's length of stay and providing greater security.(AU)

Validade do diagnóstico clínico de candidíase vulvovaginal / Validity of clinical diagnosis of vulvovaginal candidiasis

Com o objetivo de verificar a validade do diagnostico clínico para a candidíase vulvovaginal e utilizando como padrão-ouro a cultura de secreção vaginal, realizou-se uma análise em 93 pacientes atendidas pelo serviço de Ginecologia da Faculdade de Medicina de Barbacena. As pacientes procuraram o serviço por demanda espontânea, para consulta ginecológica de rotina. Foram submetidas a anamnese e exame ginecológico, com o intuito de avaliar os dados epidemiológicos, sintomas e sinais clínicos. Foi colhido material para a cultura da secreção vaginal, semeada em ágar Sabouraud. A prevalência da Candida foi de 47,91%. A acurácia do exame clínico foi de 0,78, tendo sensibilidade (S) de 82,6% e especificidade (E) de 74,46%. Os achados que tiveram relevância foram a presença de fluxo grumoso (S: 82,60% e E: 78,72%), a citologia positiva para Candida (S: 60,86% e E: 95,74%) e a presença de processo inflamatório (S: 60,86% e E: 87,23%). Os valores de OR foram estatisticamente significantes e todos obtiveram um p<0,001.

To verify the validity of clinical diagnosis of vulvovaginal candidiasis by itself and associated with fresh examination using the culture of vaginal secretion as gold standard. An analysis was carried out on 93 patients that were seen by the department of Gynecology from Faculdade de Medicina de Barbacena, which looked forward the service by spontaneous demand for routine gynecological appointment. They were subjected to a anamnesis for the evaluation of clinical symptoms and epidemiological data, the gynecological exam was performed and each data was discriminated. To make the clinical diagnosis, widely disseminated criteria by literature were used, such as vulvovaginal intense itching and burning, swelling and vulvar erythema, dyspareunia, vaginal secretions, white, flocculated, thick and inodorous. The last step was to collect material to vaginal secretion culture and sent it to a laboratory of microbiology to grow on Sabouraud agar, until 48 hours after the collection. In the study the prevalence of vulvovaginal candidiasis in patients, based on the culture, was 47.91%. The accuracy of clinical examination was a 0.78, and sensitivity (S) of 82.6% and specificity (E) of 74.46%. The findings that have great relevance were the presence of flocculated flow (S: 82.60% and E: 78.72%), positive cytology for Candida (S: 60.86% and E: 95.74%) and the presence of inflammatory process (S: 60.86% and E: 87.23%). The odds ratio of these items were also statistically significant and all get a p<0,001.